Today, my guest is Dr. Matt Kaeberlein, a CEO of Optispan, anti-aging researcher, Professor at the University of Washington, and founding Director of the University of Washington Healthy Aging and Longevity Research Institute. Dr Kaeberlein is the author of over 250 published scientific research articles on aging, healthspan, and longevity of people and companion animals. Dr. Kaeberlein is a Fellow of the American Association for the Advancement of Science, the American Aging Association, and the Gerontological Society of America. He has received numerous prestigious awards from organizations such as the Alzheimer’s Association and the National Institutes of Health. He has co-founded two companies, Ora Biomedical, Inc., a leading longevity drug discovery biotech, and Optispan, Inc., a healthcare technology company focused on developing innovative tools for 21st-century medicine. He is also the Co-Founder of the Dog Aging Project and Dog Aging Institute.

In this episode, Dr Kaeberlein explains the science and practice of nutrition and longevity. We cover animal and human research on nutrition and anti aging. We discuss calorie restriction, intermittent fasting, time-restricted eating, keto diet (ketogenic diet), protein, Mediterranean diet, and the carnivore diet. We also discuss mechanisms of aging and the most convincing human evidence for nutrition and longevity. Finally, Dr Kaeberlein gives tips and tools for everyday anti aging. We also discuss anti aging in dogs (Dog Aging Project).

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DR MATT KAEBERLEIN LINKS

Website: https://www.optispan.life/
YouTube: https://www.youtube.com/@optispan
X: https://x.com/mkaeberlein
Dog Aging Project: https://dogagingproject.org/

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DISCLAIMER
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TIMESTAMPS

00:00 Intro
00:00:25 Anti Aging Trends
00:04:00 Anti aging, longevity, and healthspan
00:11:50 Healthspan and Biology of Aging
00:13:27 Healthspan and Biology of Aging
00:14:35 Health in Organs
00:15:50 NAD, Health Decline, and Optimal Age for Anti aging
00:17:40 Reversing Aging Damage
00:19:20 Anti Aging Nutrition Research
00:21:10 Caloric Restriction, Calorie Restriction, and Protein Restriction
00:26:00 Risks of Extrapolating and Inflammation
00:28:30 Caloric Restriction, Reproduction and Hormonal Health
00:32:00 Can Ketogenic Diet Increase Lifespan
00:32:50 Genes, Keto diet and Health Benefits
00:35:20 Tool: Blood Test, Labs, DEXA, Vo2max, etc
00:37:15 Biological Age Tests
00:38:20 Human Nutritional Strategies for Anti Aging (Anti Aging diet)
00:39:00 Non-Diet Factors
00:39:40 Sugar, Protein, Continuous Glucose Monitoring, Processed Foods
00:41:20 Mediterranean Diet, MIND Diet, Alzheimer’s Disease
00:42:45 Alcohol
00:43:21 Extreme Diet and Carnivore Diet
00:44:45 Inflammation, Food Intolerance, Immunity, Allergy and Aging
00:50:00 Biological Mechanisms of Aging
00:53:00 IGF-1, mTOR, and cancer
00:54:40 mTOR and Rapamycin, FGF21
00:58:30 Dr. Matt Kaeberlein Longevity Protocol
01:04:00 Anti Aging in Dogs: Dog Aging Project